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Zoloft Sertraline hydrochloride is the most prescribed antidepressant in the U.S. Zoloft is one of its brand names, and it's prescribed as a treatment for major depression in adults, as well as obsessive-compulsive, panic and social anxiety disorders in both adults and children. Our Zoloft forum has discussions on Zoloft side effects, Zoloft interactions, and other important Zoloft information.

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